星形細(xì)胞瘤
1.毛細(xì)胞星形細(xì)胞瘤(WHO I)
陽(yáng)性:GFAP
2.室管膜下巨細(xì)胞星形細(xì)胞瘤(WHO I)
陽(yáng)性:GFAP,S-100
3.彌漫性星形細(xì)胞瘤(WHO II)
陽(yáng)性:Vimentin,GFAP,S-100,SOX2,Caveolin,Oligo-2(91%),一些PCK,P53(50%)
4.毛黏液樣星形細(xì)胞瘤
陽(yáng)性:GFAP,S-100,一些SYN
陰性:NF,CgA
5.多形性黃色星形細(xì)胞瘤(WHO II)
陽(yáng)性:GFAP,S-100,CD34,一些SYN,一些NF, Class III β-tubulin,MAP2
6.間變型星形細(xì)胞瘤(WHO III)
陽(yáng)性:GFAP,S-100,SOX2,caveolin,70%-90% P53
7.伴有神經(jīng)氈樣島的膠質(zhì)神經(jīng)元腫瘤(WHO II/III)
陽(yáng)性:膠質(zhì)成分GFAP,神經(jīng)氈樣島SYN,神經(jīng)節(jié)細(xì)胞樣細(xì)胞NeuN,Hu,P53
8.多形性膠質(zhì)母細(xì)胞瘤(WHO IV)
陽(yáng)性:GFAP,S-100,SOX2,caveolin,vimentin,>50%PCK,70%-90%P53
陰性:CAM5.2,CK7,CK20
9.巨細(xì)胞膠質(zhì)母細(xì)胞瘤(WHO IV)
陽(yáng)性:70%-90% P53
10.膠質(zhì)肉瘤(WHO IV)
陽(yáng)性:上皮分化區(qū)可呈CAM5.2,CK7,CK20
陰性:GFAP
少突膠質(zhì)腫瘤
1.少突膠質(zhì)瘤(WHO II)
陽(yáng)性:Oligo-2,S-100,CD57,SOX2
陰性caveolin
2.間變型少突膠質(zhì)瘤(WHO III)
室管膜腫瘤
1.室管膜下瘤(WHO II)
陽(yáng)性:GFAP,NCAM,NSE
2.黏液乳頭狀室管膜瘤(WHO I)
陽(yáng)性:GFAP,vimentin,S-100,AB/PAS
陰性:CK
3.室管膜瘤(WHO II)
間變型室管膜瘤(WHO III)
陽(yáng)性:EMA,CK7,CAM5.2,CK34βE12,GFAP,vimentin,S-100,SOX2,nestin,EMA,CD99,TTF-1,NeuN
脈絡(luò)叢腫瘤
脈絡(luò)叢乳頭狀瘤(WHO I)
不典型脈絡(luò)叢乳頭狀瘤(WHO II)
脈絡(luò)叢乳頭狀癌(WHO III)
陽(yáng)性:vimentin,S-100,GFAP,transthyretin,CD99,PCK,CK7,EMA,podoplanin,Kir7.1
陰性:SOX2,caveolin,NeuN,CEA,ER,Ber-Ep4,TTF-1,CK20
其他神經(jīng)上皮腫瘤
1.星形母細(xì)胞瘤
陽(yáng)性:GFAP,S-100,vimentin,EMA,LCK
陰性:CAM5.2,PCK
2.血管中心性膠質(zhì)瘤(WHO I)
陽(yáng)性:GFAP,S-100,vimentin,podoplanin,EMA
陰性:NSE,Syn,CgA,NeuN
3.第三腦室脊索樣膠質(zhì)瘤(WHO II)
陽(yáng)性:GFAP,vimentin,S-100,EMA,EGFR,merlin
陰性:P53,P21,MDM2,CK
神經(jīng)元腫瘤、膠質(zhì)神經(jīng)元混合性腫瘤
1.嬰兒促纖維增生性星形細(xì)胞瘤
嬰兒促纖維增生性節(jié)細(xì)胞膠質(zhì)瘤(WHO I)
陽(yáng)性:GFAP,S-100,Syn,NF
2.胚胎發(fā)育不良性神經(jīng)上皮腫瘤
陽(yáng)性:S-100,GFAP,Syn,NF
3.神經(jīng)節(jié)細(xì)胞膠質(zhì)瘤(WHO I或III)和神經(jīng)節(jié)細(xì)胞瘤(WHO I)
陽(yáng)性:S-100,GFAP,CD34,SOX2,Syn,NF,MAP2,NeuN
4.小腦發(fā)育不良性神經(jīng)節(jié)細(xì)胞瘤(WHO I)
陽(yáng)性:S-100,Syn,NF,p-AKT,p-S6,Leu-4,L7,PEP19,calbindin
陰性:PTEN
5.乳頭狀膠質(zhì)神經(jīng)元腫瘤(WHO I)
陽(yáng)性:Syn,NSE,CD56,β-tubulin,NeuN,NF,GFAP,Oligo-2
6.第四腦室伴有菊形團(tuán)形成的膠質(zhì)神經(jīng)元腫瘤(WHO I)
陽(yáng)性:Syn,NSE,MAP2,GFAP,S-100
7.中樞神經(jīng)細(xì)胞瘤(WHO II)和腦室外神經(jīng)細(xì)胞瘤
陽(yáng)性:Syn,NeuN
陰性:GFAP,NF,CgA
8.小腦脂肪神經(jīng)細(xì)胞瘤(WHO II)和腦室外神經(jīng)細(xì)胞瘤
陽(yáng)性:NSE,MAP2,Syn,GFAP,NeuN
松果體區(qū)腫瘤
1.松果體細(xì)胞瘤(WHO I)
陽(yáng)性:Retinal S-antigen,Syn,NSE,NF,β-tubulin(Class III),tau,PGP9.5,CgA
2.中等分化的松果體實(shí)質(zhì)腫瘤(WHO II)
陽(yáng)性:Syn,NSE,NF,Retinal S-antigen,CgA
3.松果體母細(xì)胞瘤(WHO III)
陽(yáng)性:Syn,NSE,NF,β-tubulin(Class III),CgA,Retinal S-antigen
4.松果體區(qū)乳頭狀腫瘤(WHO II/III)
陽(yáng)性:PCK,CAM5.2,CK18,vimentin,S-100,NSE,MAP2,NCAM,transthyretin,GFAP,EMA
陰性:NF
胚胎性腫瘤
1.髓母細(xì)胞瘤
陽(yáng)性:神經(jīng)細(xì)胞標(biāo)志(Syn,NSE,NeuN,NF,β-tubulin),GFAP,PCK,EMA
陰性:CD99,SOX2
2.中樞神經(jīng)系統(tǒng)的原始神經(jīng)外胚葉瘤(WHO IV)
陽(yáng)性:Syn,NSE,NeuN,NF,β-tubulin,vimentin,GFAP
3.髓上皮瘤(WHO IV)
陽(yáng)性:nestin,vimentin,CK,EMA,NF,Syn,β-tubulin,GFAP
4.室管膜母細(xì)胞瘤(WHO IV)
陽(yáng)性:S-100,vimentin
5.不典型畸胎樣或橫紋肌樣瘤(WHO IV)
陽(yáng)性:GFAP,S-100,Syn,NF,vimentin,SMA,EMA
神經(jīng)鞘瘤、神經(jīng)纖維瘤、神經(jīng)束膜瘤、惡性外周神經(jīng)鞘瘤
腦膜腫瘤
腦膜瘤(WHO I)
不典型腦膜瘤(WHO II)
間變型腦膜瘤(WHO II)
陽(yáng)性:vimentin,claudin 1,PCK,CK7,CK19,CAM5.2,S-100,EMA
陰性:CD34,GFAP
腦膜黑色素細(xì)胞瘤、彌漫性黑色素細(xì)胞增生和惡性黑色素瘤
陽(yáng)性:S-100,Melan-A
淋巴造血組織腫瘤
生殖細(xì)胞腫瘤
1.生殖細(xì)胞瘤
陽(yáng)性:PLAP,CD117,OCT-4;若有合體滋養(yǎng)葉細(xì)胞樣成分,可呈β-HCG,h-PL,CK
陰性:CD30,AFP
2.胚胎癌
陽(yáng)性:CK,PLAP,CD30,OCT-4
陰性CD117,AFP,EMA
3.卵黃囊瘤或內(nèi)胚竇瘤
陽(yáng)性:AFP,CK
陰性:CD117,OCT-4,β-HCG,h-PL,CD30
4.絨毛膜癌
陽(yáng)性:β-HCG,h-PL,CK
陰性:CD117,OCT-4,CD30,AFP
5.畸胎瘤和混合型生殖細(xì)胞腫瘤
鞍區(qū)腫瘤
1.腺垂體梭形細(xì)胞嗜酸細(xì)胞瘤(WHO I)
陽(yáng)性:vimentin,EMA,S-100,Galectin-3
陰性:CK,GFAP,Syn,CgA,SMA,desmin,CD34
2.神經(jīng)垂體細(xì)胞瘤(WHO I)
陽(yáng)性:S-100,GFAP
陰性:CK,Syn,CgA
3.神經(jīng)垂體顆粒細(xì)胞瘤(WHO I)
陽(yáng)性:S-100
4.顱咽管瘤(WHO I)
陽(yáng)性:PCK,HCK,LCK,P63,CK7,β-catenin
其他腫瘤
1.脊索瘤
陽(yáng)性:PCK,EMA,S-100
2.內(nèi)淋巴囊瘤
陽(yáng)性:PCK,EMA
3.嗅神經(jīng)母細(xì)胞瘤
陽(yáng)性:Syn,NF,MAP2,S-100
陰性:CD99
4.小腦血管母細(xì)胞瘤
陽(yáng)性:間質(zhì)細(xì)胞呈S-100,NSE,CD56,vimentin,Inhibin-α,D2-40
陰性:EMA,CD10,CAM5.2,RCC
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