中文字幕理论片,69视频免费在线观看,亚洲成人app,国产1级毛片,刘涛最大尺度戏视频,欧美亚洲美女视频,2021韩国美女仙女屋vip视频

　　關(guān)于睡眠持續(xù)時間對于乳腺癌發(fā)生風(fēng)險有利或不利影響的研究證據(jù)仍然存在爭議和局限性，尤其對于亞洲人群。

　　2018年11月20日，施普林格·自然旗下《乳腺癌研究與治療》在線發(fā)表日本大阪大學(xué)、北海道大學(xué)、埃及米尼亞大學(xué)、日本人群研究協(xié)作組的大數(shù)據(jù)研究報告，分析了睡眠持續(xù)時間與乳腺癌發(fā)生風(fēng)險的相關(guān)性（注：相關(guān)性≠必然性）。

　　該前瞻研究對3萬4350位年齡40～79歲日本女性進行調(diào)查和隨訪，其中睡眠持續(xù)時間、月經(jīng)史、生育史通過自填問卷獲得，隨訪時間為1988～2009年，并且通過多因素比例風(fēng)險回歸模型，計算每天睡眠持續(xù)時間<8小時與≥8小時的乳腺癌發(fā)生風(fēng)險比及其95%置信區(qū)間。

　　結(jié)果，中位19.2年隨訪期間發(fā)生乳腺癌236例，睡眠持續(xù)時間與乳腺癌發(fā)生風(fēng)險成反比，尤其是絕經(jīng)后女性和生育較少（未生育和孩子少于3個）女性。

　　校正其他多種影響因素后，每天睡眠持續(xù)時間與絕經(jīng)后女性的乳腺癌發(fā)生風(fēng)險成反比（趨勢分析P=0.028）

• 7小時與≥8小時相比：風(fēng)險增加49%（風(fēng)險比：1.49，95%置信區(qū)間：0.81～2.76）

• ≤6小時與≥8小時相比：風(fēng)險增加98%（風(fēng)險比：1.98，95%置信區(qū)間：1.08～3.70）

　　校正其他多種影響因素后，每天睡眠持續(xù)時間與生育較少女性的乳腺癌發(fā)生風(fēng)險成反比（趨勢分析P=0.018）

• 7小時與≥8小時相比：風(fēng)險增加50%（風(fēng)險比：1.50，95%置信區(qū)間：0.96～2.35）

• ≤6小時與≥8小時相比：風(fēng)險增加76%（風(fēng)險比：1.76，95%置信區(qū)間：1.01～2.79）

　　因此，該研究結(jié)果表明，睡眠持續(xù)時間較短與乳腺癌發(fā)生風(fēng)險增加相關(guān)，尤其對于絕經(jīng)后和生育較少的女性。

　　注：本文并非科普文章，僅供專業(yè)人士參考，切忌向無專業(yè)知識的讀者轉(zhuǎn)發(fā)，以免不必要的誤讀和誤解，謝謝！

相關(guān)閱讀

• 睡眠特征對乳腺癌進展結(jié)局的影響

• 睡眠飲食不合時宜增加乳腺癌風(fēng)險

• 乳腺癌女性的睡眠質(zhì)量與持續(xù)時間

• 乳腺癌女性的睡眠與生存

• 睡眠不足可能增加乳腺癌患病風(fēng)險

Breast Cancer Res Treat. 2018 Nov 20.

Sleep duration and risk of breast cancer: The JACC Study.

Cao J, Eshak ES, Liu K, Muraki I, Cui R, Iso H, Tamakoshi A; JACC Study Group.

Osaka University Graduate School of Medicine, Osaka, Japan; Minia University, Minia, Egypt; Hokkaido University, Sapporo, Japan.

PURPOSE: The evidence on beneficial or adverse effects of sleep duration on risk of breast cancer remains controversial and limited, especially in Asia.

METHODS: A prospective study of 34,350 women aged 40-79 years in whom sleep duration, and menstrual and reproductive histories were determined by a self-administered questionnaire. The follow-up period was from 1988 to 2009, and hazard ratios (HRs) with 95% confidence intervals (CIs) of breast cancer incidence were calculated for shorter sleep duration in reference to sleep duration of ≥ 8 h/day by Cox proportional hazard models.

RESULTS: During 19.2-year median follow-up (236 cases), we found a significant inverse association between sleep duration and risk of breast cancer, especially among postmenopausal women and women with low parity (nulliparous and women with < 3 children); the multivariable HRs (95% CIs) among postmenopausal women who reported 7 h/day and ≤ 6 h/day of sleep in reference to ≥ 8 h/day were 1.49 (0.81-2.76) and 1.98 (1.08-3.70) (P for trend = 0.028), respectively, and the corresponding values among women with low parity were 1.50 (0.96-2.35) and 1.76 (1.01-2.79) (P for trend = 0.018).

CONCLUSIONS: Short sleep duration was associated with increased risk of incident breast cancer, especially among postmenopausal women and women with low parity.

KEYWORDS: Breast cancer; Cohort study; Incidence; Japan; Parity; Postmenopausal; Sleep duration

PMID: 30460465

DOI: 10.1007/s10549-018-4995-4